Introduction: The aim of this study was to identify the perceived challenges of girls with disabilities about love.Materials and Methods: The study was a qualitative study and the target population included single girls with physical disabilities aged 18 years and older in Isfahan, Iran. Data were obtained through in-depth interviews with 16 girls with physical disabilities who were selected through purposive sampling from among the girls referring to two service centers for people with physical disabilities. Data analysis was performed using the Colaizzi’s method.Results: The challenges of girls with physical disabilities about love were generally divided into two categories of challenges related to the inside and outside world. Internal challenges included personal experiences, fears, beliefs, and psychological defenses, and external challenges included law, culture, suggestions, and advocacy.Conclusion: People with physical disabilities face challenges related to themselves and society when dealing with love. Paying attention to these challenges can help empower these people to deal with them appropriately.