Journal of Research in Rehabilitation Sciences

The Effect of Different Types of Aerobic Protocols with Different Intensity and Duration on the Management and Recovery of Breast Cancer in Preclinical Studies: A Brief Review

Document Type : Short Communications

Authors

1 Associate Professor, Department of Exercise Physiology, School of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran

2 PhD Student, Department of Exercise Physiology, School of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran

10.48305/jrrs.2021.31033

Abstract

Exercise is effective in preventing and controlling the progression of breast cancer. By inhibiting the growth and metastasis of cancer, physical activity can help manage and delay the side effects caused by cancer and its treatment. It can also increase people's tolerance and adherence to treatment and improve their quality of life. As ethical limitations exist for studying human samples, animal models are suitable for identifying the mechanism of the effect of various diseases in the body and the impact of proposed treatments. Based on these studies, continuous moderate aerobic and intermittent intense exercises, each through different mechanisms, can help prevent cancer, accelerate the treatment process, and reduce and delay complications caused by the disease or its medical and pharmaceutical treatment methods. However, more research is needed to study the molecular mechanisms of the effect of these exercise protocols in greater detail. Finally, research shows that the intensity, duration, and frequency of exercise are important factors that determine the treatment results in cancer control. Therefore, conducting more preclinical and clinical studies in this field is strongly recommended.

Keywords

  1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68(6): 394-424.
  2. Nafissi N, Khayamzadeh M, Zeinali Z, Pazooki D, Hosseini M, Akbari ME. Epidemiology and histopathology of breast cancer in Iran versus other Middle Eastern countries. Middle East J Cancer 2018; 9(3): 243-51.
  3. Mann RM, Hooley R, Barr RG, Moy L. Novel approaches to screening for breast cancer. Radiology 2020; 297(2): 266-85.
  4. Ligibel JA, Basen-Engquist K, Bea JW. weight management and physical activity for breast cancer prevention and control. Am Soc Clin Oncol Educ Book 2019; 39: e22-e33.
  5. Ortega MA, Fraile-Martinez O, Garcia-Montero C, Pekarek L, Guijarro LG, Castellanos AJ, et al. Physical activity as an imperative support in breast cancer management. Cancers (Basel) 2020; 13(1).
  6. Salgado TM, Quinn CS, Krumbach EK, Wenceslao I, Gonzalez M, Reed HL, et al. Reporting of paclitaxel-induced peripheral neuropathy symptoms to clinicians among women with breast cancer: a qualitative study. Support Care Cancer 2020; 28(9): 4163-72.
  7. Del-Rosal-Jurado A, Romero-Galisteo R, Trinidad-Fernandez M, Gonzalez-Sanchez M, Cuesta-Vargas A, Ruiz-Munoz M. therapeutic physical exercise post-treatment in breast cancer: A systematic review of clinical practice guidelines. J Clin Med 2020; 9(4).
  8. Boing L, Vieira MCS, Moratelli J, Bergmann A, Guimaraes ACA. Effects of exercise on physical outcomes of breast cancer survivors receiving hormone therapy - A systematic review and meta-analysis. Maturitas 2020; 141: 71-81.
  9. Saedmocheshi S, Saghebjoo M, Vahabzadeh Z, Sheikholeslami-Vatani D. Aerobic training and green tea extract protect against N-methyl-N-nitrosourea-induced prostate cancer. Med Sci Sports Exerc 2019; 51(11): 2210-6.
  10. Ashcraft KA, Peace RM, Betof AS, Dewhirst MW, Jones LW. Efficacy and mechanisms of aerobic exercise on cancer initiation, progression, and metastasis: A critical systematic review of in vivo preclinical data. Cancer Res 2016; 76(14): 4032-50.
  11. Faustino-Rocha AI, Silva A, Gabriel J, Gil da Costa RM, Moutinho M, Oliveira PA, et al. Long-term exercise training as a modulator of mammary cancer vascularization. Biomed Pharmacother 2016; 81: 273-80.
  12. Figueira ACC, Cortinhas A, Soares JP, Leitao JC, Ferreira RP, Duarte JA. Efficacy of exercise on breast cancer outcomes: A systematic review and meta-analysis of preclinical data. Int J Sports Med 2018; 39(5): 327-42.
  13. Siewierska K, Malicka I, Kobierzycki C, Paslawska U, Cegielski M, Grzegrzolka J, et al. The impact of exercise training on breast cancer. In Vivo 2018; 32(2): 249-54.
  14. Masoudzade G, Barari A, Amini S. Synergistic effect of aloe vera extract and aerobic training on tumor weight and volume and levels of interleukin 6 and vascular endothelial growth factor in mice with breast cancer. Iran J Breast Dis 2019; 11(4): 17-27. [In Persian].
  15. Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC. Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 2020; 9(3).
  16. Wennerberg E, Lhuillier C, Rybstein MD, Dannenberg K, Rudqvist NP, Koelwyn GJ, et al. Exercise reduces immune suppression and breast cancer progression in a preclinical model. Oncotarget 2020; 11(4): 452-61.
  17. Nezamdoost Z, Saghebjoo M, Hoshyar R, Hedayati M, Keska A. High-intensity training and saffron: Effects on breast cancer-related gene expression. Med Sci Sports Exerc 2020; 52(7): 1470-6.
  18. Wang B, Xu H, Hu X, Ma W, Zhang J, Li Y, et al. Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway. Life Sci 2020; 245: 117387.
  19. Barra NG, Fan IY, Gillen JB, Chew M, Marcinko K, Steinberg GR, et al. High intensity interval training increases natural killer cell number and function in obese breast cancer-challenged mice and obese women. J Cancer Prev 2017; 22(4): 260-6.
  20. Gholamian S, Attarzadeh Hosseini SR, Rashidlamir A, Aghaalinejad H. The effects of interval aerobic training on mesenchymal biomarker gene expression, the rate of tumor volume, and cachexia in mice with breast cancer. Iran J Basic Med Sci 2020; 23(2): 244-50.
  21. Khori V, Amani SS, Isanejad A, Alizadeh AM, Alizadeh S, Khodayari S, et al. Effects of exercise training together with tamoxifen in reducing mammary tumor burden in mice: Possible underlying pathway of miR-21. Eur J Pharmacol 2015; 765: 179-87.
  22. Sadeghipoor Vojdani F, Agha-Alinejad H, Molanouri Shamsi M, Soudi S, Khanchi S. The effect of interval training on the expression of tumor suppressor gene, systemic inflammation, and tumor volume in breast cancerī€­bearing BALB/c mice. Iran J Breast Dis 2019; 12(3): 17-25. [In Persian].
  23. Nasiri M, Peeri M, Matinhomaee H. The comparison of highintensity interval training versus continuous training on the expression of ErbB3 in breast cancer bearing mice. Iran J Breast Dis 2016; 9(3): 25-30. [In Persian].
  24. Ahmadian M, Azizbeigi K, Delphan M, Atashak S. The effect of high intensity interval training on STAT-3 and angiopoietin-1 gene expression, and tie-2 protein in mice with breast cancer. Iran J Basic Med Sci 2018; 11(1): 37-46. [In Persian].
Journal of Research in Rehabilitation Sciences
Volume 17, Issue 1 - Serial Number 1
April 2021
Pages 191-195